Luteolin attenuates PM2.5-induced inflammatory responses by augmenting HO-1 and JAK-STAT expression in murine alveolar macrophages

To explore the involved mechanisms and possible treatments of ambient PM2.5 exposure-induced lung inflammation, this work studied activity luteolin, a natural flavonoid which widely presents in many plant species, murine alveolar macrophage MH S cells exposed to PM2.5. Results showed induced an inflammatory response, as evidenced by significantly increased TNF-α, IL-6, MCP-1 Rantes levels. iNOS, COX-2, NF-κB protein expressions MH-S cells. Moreover, luteolin pre-treatment reduced JAK2 STAT1 but not STAT3 PM2.5-stimulated Performing inhibitor AG490 further TNF-α IL-6 productions well expressions. In addition, although exposure could elevate HO-1 expression basically, administration enhanced additionally. Collectively, these results revealed that inhibits inflammation through suppressing JAK2/STAT1/NF-κB pathway enhancing PM2.5-challenged